Enteric and colonic delivery using HPMC capsules
AssigneeWarner-Lambert Company
InventorsRobert A. Scott, Ewart T. Cole
Life of this patent
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Abstract
The invention provides a drug delivery system for delivering a drug to either the small intestine (enteric) or the colon comprising a HPMC capsule containing the drug and wherein the HPMC capsule is provided with a suitable coating such that the drug is released from the capsule either in the small intestine or the colon.
Claims28
A drug delivery composition consisting essentially of a coated HPMC capsule capable of containing a drug, wherein the HPMC capsule comprises a single aqueous coating such that the drug is not released from the capsule in the stomach.
A drug delivery composition consisting essentially of an HPMC capsule capable of containing a drug, wherein:
- (a) drug is not released from the capsule in the stomach;
- (b) one half of the capsule is enteric coated and the other half is colonic coated;
- (c) the enteric coating is at least one member selected from the group consisting of cellulose acetate trimellitiate, hydroxypropylmethyl cellulose phthalate, polyvinyl acetate phthalate, shellac, and a copolymer of methacrylic acid and ethyl acrylate:
- and (d) the colonic coating is a member selected from the group consisting of azopolymers, disulphide polymers and amylose.
Dependencies are inferred from the claim text.