Cationic lipid compositions targeting angiogenic endothelial cells
AssigneeThe Regents of the University of California
InventorsDonald M. McDonald, John McLean, O. Gavin Thurston, Peter Baluk
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Abstract
Angiogenic endothelial cells are selectively targeted with lipid/DNA complexes or cationic liposomes containing a substance which affects the targeted cells by inhibiting or promoting their growth. A site of angiogenesis can be precisely located by administering cationic liposomes containing a detectable label. The complexes may comprise nucleotide constructs which are comprised of promoters which are selectively and exclusively activated in the environment of an angiogenic endothelial cell.
Claims9
A method for selectively labeling angiogenic endothelial cells in vivo, the method comprising administering to a mammal a liposomal complex comprising cationic lipids and a detectable label wherein the complex has greater affinity for angiogenic endothelial cells as compared to corresponding normal endothelial cells;
- and allowing the liposomal complex to selectively associate with angiogenic endothelial cells of an angiogenic blood vessel for a time and in a manner such that the angiogenic endothelial cells are detectably labeled.
Dependencies are inferred from the claim text.