Topical delivery of antifungal agents
AssigneeAcrux DDS Pty Ltd
InventorsNora Yat Knork Chew, Barry Leonard Reed, Timothy Matthias Morgan, Barrie Charles Finnin
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Abstract
The present invention provides a topical drug delivery system which comprises: a therapeutically effective amount of an antifungal agent; at least one dermal penetration enhancer, which is a safe skin-tolerant ester sunscreen ester; and a volatile liquid. The invention also provides a method for administering at least one systemic acting antifungal agent to an animal which comprises applying an effective amount of the antifungal agent in the form of the drug delivery system of the present invention.
Claims16
A topical drug delivery system which comprises:
- a. a therapeutically effective amount of an antifungal agent;
- b. at least one dermal penetration enhancer, which is a safe skin-tolerant ester sunscreen of formula (I):
- wherein
- R1 is hydrogen, lower alkyl, lower alkoxy, halide, hydroxy or NR3R4;
- R2 is a C8 to C18 alkyl,
- R3 and R4 are each independently hydrogen, lower alkyl or R3 and R4 together with the nitrogen atom to which they are attached form a 5- or 6-membered heterocyclic ring;
- n is 0 or 1, and
- q is 1 or 2,
- wherein when n is 0 and R1 is NR3 R4, then NR3 R4 is para-substituted;
- and wherein said dermal penetration enhancer is present in an amount of from about 10 to about 10,000 wt % based on the weight of the antifungal agent;
- and
- c. a volatile liquid.
Dependencies are inferred from the claim text.