Antigen arrays for treatment of allergic eosinophilic diseases

A composition comprising:

• (a) a core particle with at least one first attachment site, wherein said core particle is a virus-like particle or a recombinant form thereof;
• and
• (b) at least one antigen or antigenic determinant with one or more second attachment sites;
• wherein said antigen or antigenic determinant is a protein or peptide of IL-5, IL-13 or eotaxin, and wherein said one or more second attachment sites are selected from the group consisting of:
• (i) an attachment site not naturally occurring with said antigen or antigenic determinant;
• and
• (ii) an attachment site naturally occurring with said antigen or antigenic determinant,
• wherein only one of said second attachment sites associates with said first attachment site through at least one non-peptide covalent bond leading to a single and uniform type of binding of said antigen to said core particle, wherein said only one second attachment site that associates with said first attachment site is a sulfhydryl group, and wherein said antigen or antigenic determinant and said core particle interact through said association to form an ordered and repetitive antigen array.

A composition comprising:

• (a) at least one first core particle and at least one second core particle with each core particle comprising at least one first attachment site;
• and
• (b) at least one first antigen or antigenic determinant and at least one second antigen or antigenic determinant with each antigen or antigenic determinant comprising at least one second attachment site;
• wherein said first antigen or antigenic determinant and said second antigen or antigenic determinant is selected from a protein or peptide of IL-5, IL-13 or eotaxin, and wherein said first antigen or antigenic determinant is different from said second antigen or antigenic determinant, and wherein said second attachment site is selected from the group consisting of:
• (i) an attachment site not naturally occurring with said antigen or antigenic determinant;
• and
• (ii) an attachment site naturally occurring with said antigen or antigenic determinant, and
• wherein, through said first and said second attachment sites, said first core particle interacts with said first antigen or antigen determinant to form an ordered and repetitive antigen array, and said second core particle interacts with said second antigen or antigen determinant to form an ordered and repetitive antigen array.