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AssigneeThe United States of America as represented by the Secretary of the Department of Health and Human Services and Genelabs Technologies, Inc.
InventorsGregory R. Reyes, Patrice O. Yarbough, Daniel W. Bradley, Krzysztof Z. Krawczynski, Albert W. Tam, Kirk E. Fry
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Viral proteins derived from an enterically transmitted non-A/non-B viral hepatitis agent (HEV) are disclosed. In one embodiment, the protein is immunologically reactive with antibodies present in individuals infected with the viral hepatitis agent. This protein is useful in a diagnostic method for detecting infection by the enterically transmitted agent. Specific epitopes have been identified that are reactive with sera of individual infected with different strains of HEV. Also disclosed are DNA probes derived from a cloned sequence of the viral agent. These probes are useful for identifying and sequencing the entire viral agent and for assaying the presence of the viral agent in an infected sample, by using probe-specific amplification of virus-derived DNA fragments.
A composition comprising an isolated peptide prepared by expressing an expression vector wherein said expression vector comprises a nucleic acid selected from the group consisting of the sequence shown from base number 5147 through 7129 in SEQ ID NO:6 and the sequence shown from base number 5117 through 7096 in SEQ ID NO:10, said peptide being specifically immunoreactive with hepatitis E virus (HEV) antibodies.
A composition comprising an isolated peptide prepared by expressing an expression vector wherein said expression vector comprises a nucleic acid homologous to nucleic acid selected from the group consisting of the sequence shown from base number 5147 through 7129 in SEQ ID NO:6 and the sequence shown from base number 5117 through 7096 in SEQ ID NO:10;
A composition comprising an isolated peptide prepared by expressing an expression vector wherein said expression vector comprises a fragment of at least 30 nucleotides of a nucleic acid selected from the group consisting of the sequence shown from base number 5147 through 7129 in SEQ ID NO:6 and the sequence shown from base number 5117 through 7096 in SEQ ID NO:10.
Dependencies are inferred from the claim text.