Antibodies to human interleukin-11 receptor
AssigneeGenetics Institute, Inc.
InventorJames Tobin
Life of this patent
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Abstract
Polynucleotides encoding the human IL-11 receptor and fragments thereof are disclosed. IL-11 receptor proteins, methods for their production, antibodies to human IL-11 receptor, inhibitors of binding of human IL-11 and its receptor and methods for identification of their receptor are also disclosed.
Claims12
An isolated antibody that specifically binds to a human interleukin-11 receptor (IL-11R) protein or a fragment thereof, wherein the human IL-11R protein or fragment thereof consists of an amino acid sequence selected from the group consisting of:
- (a) the amino acid sequence of SEQ ID NO:2;
- (b) the amino acid sequence of SEQ ID NO:2 from amino acids 24 to 422;
- (c) the amino acid sequence of SEQ ID NO:2 from amino acids 24 to 365;
- (d) the amino acid sequence of SEQ ID NO:2 from amino acids 391 to 422;
- (e) the amino acid sequence of SEQ ID NO:2 from amino acids 112 to 422;
- (f) the amino acid sequence of SEQ ID NO:2 from amino acids 112 to 365;
- (g) the amino acid sequence of SEQ ID NO:2 from amino acids 24 to 359;
- (h) the amino acid sequence of SEQ ID NO:2 from amino acids 24 to 345;
- and
- (i) the amino acid sequence of SEQ ID NO:2 from amino acids 24 to 324.
An isolated antibody that specifically binds to a human interleukin-11 receptor (IL-11R) consisting of the amino acid sequence of SEQ ID NO:2 or consisting of the amino acid sequence of SEQ ID NO:2 from amino acids 24 to 422.
Dependencies are inferred from the claim text.