Method for making cytokine specific antibodies and uses thereof
AssigneeLudwig Institiute for Cancer Research
InventorsJacques Van Snick, Jean Christophe Renauld, Mélisande Richard
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Abstract
The methods of this invention relate to immunizing animals with conjugates of cytokines and a carrier to induce a prolonged high titre antibody response specific for the cytokine. This invention also relates to the treatment of pathological conditions, e.g., eosinophilia and allograft rejection, associated with the production of cytokines, in particular interleukins, e.g., IL-4, IL-5, IL-9, and IL-13, by immunization with the cytokine conjugates or by administration of antibodies specific for the cytokine. This invention also relates to compositions comprising the cytokine conjugates and the conjugates per se.
Claims19
A method for inhibiting interleukin-9 (IL-9) activity in a subject suffering from a condition selected from the group consisting of excess lymphomagenesis, intestinal mastocytosis, overexpansion of β1 lymphocytes, and bronchial hyperresponsiveness, comprising administering an amount of a conjugate of IL-9 and a carrier to said subject, in an amount sufficient to induce production of antibodies which bind to and neutralize IL-9, and to alleviate said condition.
A method for inducing an elevated titer of an antibody which is specific for and neutralizes interleukin-9 (IL-9), comprising administering to a subject an amount of a conjugate of IL-9 and a carrier in an amount sufficient to provoke production of antibodies which are specific to IL-9 wherein the elevated titer of said antibody persists for at least six months following immunization.
Dependencies are inferred from the claim text.