Methods and compositions for controlling biofilm development

A biofilm removing or inhibiting composition comprising an effective amount for regulating biofilm development of a compound selected from the group consisting of blockers of N-(3-oxododecanoyl) L-homoserine lactone (OdDHL), and analogs of butyryl L-homo-serine lactone (BHL), and mixtures thereof, and a vehicle or carrier, wherein the amount of the compound is effective to remove or disrupt a bacterial biofilm or inhibit normal biofilm formation, and wherein an effective amount for regulating biofilm development of blockers of N-(3-oxododecanoyl) L-homoserine lactone is between about 2.5 μM and 50 μM, and effective amount for regulating biofilm development of analogs of butyryl L-homoserine lactone is between about 5 μM and 100 μM.