Compositions and methods for administering Borrelia burgdorferi antigens
AssigneeThe University of Texas System
InventorsAlan G. Barbour, Catherine J. Luke
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Abstract
Mucosal administration of OspA and compositions therefor are disclosed and claimed. More particularly, oral administration of OspA and compositions therefor for eliciting an immunological response against Borrelia burgdorferi, such as a protective response preventive of Lyme disease are disclosed and claimed. Thus, oral Lyme disease vaccines or immunological compositions and methods of use are disclosed and claimed.
Claims7
A method for inducing an immunological response, including OspA specific serum IgA antibodies in a mammalian host susceptible to Lyme disease or Borrelia burgdorferi infection comprising orally administering a composition comprising substantially pure outer surface protein A (OspA) and a carrier or diluent which is free of any immunogenicity-enhancing adjuvant.
Dependencies are inferred from the claim text.