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US 7,094,347 B2Granted
Positively charged membrane
AssigneePall Corporation
InventorsXiaosong Wu, Chung-Jen Hou, Jayesh Dharia, Peter Konstantin, Yujing Yang
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AssigneePall Corporation
InventorsXiaosong Wu, Chung-Jen Hou, Jayesh Dharia, Peter Konstantin, Yujing Yang
Estimating the term…
The present invention provides a positively charged microporous membrane having a protein binding capacity of about 25 mg/ml or greater comprising a hydrophilic porous substrate and a crosslinked coating that provides a fixed positive charge to the membrane. The present invention further provides a positively charged microporous membrane comprising a porous substrate and a crosslinked coating comprising pendant cationic groups. The membranes of the present invention find use in a variety of applications including ion-exchange chromatography, macromolecular transfer, as well as detection, filtration and purification of biomolecules such as proteins, nucleic acids, endotoxins, and the like.
A fluid treatment element comprising a plurality of positively charged microporous membranes, each positively charged microporous membrane comprising a porous substrate and a crosslinked coating having pendant positively charged groups, wherein the crosslinked coating includes a copolymer of diallylamine, diallyldialkylammonium halide, acrylic monomer having a quaternary ammonium group, and a crosslinking agent.
A fluid treatment element comprising a plurality of positively charged microporous membranes, each positively charged microporous membrane comprising a porous substrate and a crosslinked coating having pendant positively charged groups, wherein the crosslinked coating includes an acrylic polymer having epoxy groups and pendant positively charged groups and a copolymer comprising a polyamine and a glycidyl compound having a positively charged group.
A fluid treatment device comprising a housing comprising at least one inlet and at least one outlet and defining a fluid flow path between the inlet and the outlet, and, interposed between the inlet and the outlet and across the fluid flow path, a plurality of positively charged microporous membranes, each positively charged microporous membrane comprising a porous substrate and a crosslinked coating having pendant positively charged groups, wherein the crosslinked coating includes a copolymer of diallylamine, diallyldialkylammonium halide, acrylic monomer having a quaternary ammonium group, and a crosslinking agent.
A fluid treatment device comprising a housing comprising at least one inlet and at least one outlet and defining a fluid flow path between the inlet and the outlet, and, interposed between the inlet and the outlet and across the fluid flow path, a plurality of positively charged microporous membranes, each positively charged microporous membrane comprising a porous substrate and a crosslinked coating having pendant positively charged groups, wherein the crosslinked coating includes an acrylic polymer having epoxy groups and pendant positively charged groups and a copolymer comprising a polyamine and a glycidyl compound having a positively charged group.
A fluid treatment element comprising a plurality of positively charged microporous membranes, each positively charged microporous membrane comprising a porous substrate and a crosslinked coating having pendant positively charged groups, wherein the crosslinked coating comprises a crosslinked polyamine and an acrylic copolymer.
A fluid treatment device comprising a housing comprising at least one inlet and at least one outlet and defining a fluid flow path between the inlet and the outlet, and, interposed between the inlet and the outlet and across the fluid flow path, a plurality of positively charged microporous membranes, each positively charged microporous membrane comprising a porous substrate and a crosslinked coating having pendant positively charged groups, wherein the crosslinked coating comprises a crosslinked polyamine and an acrylic copolymer.
Dependencies are inferred from the claim text.