Systems and methods for delivering drugs to selected locations within the body

A reservoir device for providing sustained delivery of a drug within the cardiovascular system of a patient, comprising:

• a substantially cylindrical frame adapted to expand between a collapsed condition for insertion into a blood vessel and an enlarged condition for engaging a wall of the blood vessel, the frame defining a longitudinal axis and a periphery;
• and
• a flexible membrane attached to the frame, the membrane including a generally cylindrical periphery with transversely disposed end panels attached to the periphery to define a generally cylindrical reservoir having closed ends, a porous region being disposed along at least a portion of the periphery of the flexible membrane such that drug that has been injected into the reservoir will pass out of the reservoir through said porous region
• at least one of said end panels being formed of material which can be penetrated by a hollow needle through which drug may be injected into the reservoir and which will automatically reseal after the needle is withdrawn.