Back to results
US 7,091,186 B2Granted
p-Amidobenzylethers in drug delivery agents
AssigneeSeattle Genetics, Inc.
InventorsPeter D. Senter, Brian E. Toki
Life of this patent
Estimating the term…
Abstract
Compounds of the formulae LAn-Z-X—WwD and BZ-X—WwD wherein: D is a drug moiety; L is a ligand; B is a blocking group; A is an optional acyl unit; Z is an amino acid or a peptide residue; X is an aminobenzyl ether self-immolative spacer group; W is an optional second self-immolative group; n is an integer of 0 or 1; and w is an integer of 0 or 1, and compositions of said compounds with pharmaceutically acceptable carrier, diluent and/or excipient, and methods of delivery the drug D via the compounds.
Claims38
A compound of the formula:
- BZ-X—WwD
- wherein:
- D is a drug moiety;
- B is a blocking group;
- Z is an amino acid or a peptide residue;
- X is an aminobenzyl ether self-immolative group;
- W is an optional second self-immolative group;
- w is an integer of 0 or 1;
- wherein X—W forms an aminobenzyl ether when w is 1, and X-D forms an aminobenzyl ether when w is 0.
6 more elements
Dependencies are inferred from the claim text.