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US 7,091,048 B2Granted
High throughput screening assay systems in microscale fluidic devices
OwnerJ. Wallace Parce, Anne R. Kopf-Sill +1inventors
InventorsJ. Wallace Parce, Anne R. Kopf-Sill, Luc J. Bousse
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Abstract
The present invention provides novel microfluidic devices and methods that are useful for performing high-throughput screening assays. In particular, the devices and methods of the invention are useful in screening large numbers of different compounds for their effects on a variety of chemical, and preferably, biochemical systems.
Claims13
A method for transporting a test or sample compound, comprising:
- (a) providing a first channel having an inlet end connected to one or more sources of a test or sample compound and an outlet end connected to a main sample channel;
- (b) providing a second channel having an inlet end connected to at least one source of a spacer fluid and an outlet end connected to the main sample channel;
- (c) drawing a first volume of spacer fluid into the second channel and transporting the volume of spacer fluid into the main sample channel;
- (d) drawing at least a first test or sample compound into the first channel and transporting the at least first test or sample compound Into the main sample channel after the first volume of spacer fluid;
- (e) drawing a second volume of spacer fluid into the second channel and transporting the second volume of spacer fluid into the main sample channel after the at least first test or sample compound such that the first rest or sample compound is located between the first and second volumes of spacer fluid in the main sample channel.
2 more elements
Dependencies are inferred from the claim text.