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US 7,090,981 B2Granted
Chicken anaemia viruses of low pathogenicity
AssigneeAkzo Nobel N.V.
InventorsCarla Christina Schrier, Henricus Johannes Maria Jagt
Life of this patent
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Abstract
The present invention provides a new antigenic type of chicken anaemia viruses (CAV). The CAV according to this invention is isolatable from turkeys in the field and its virulence for chickens is significantly reduced. This property makes these viruses particularly suited for preparing a live vaccine for protecting poultry against disease conditions resulting from CAV infection.
Claims6
A method for the preparation of CAV, comprising the steps of:
- a. inoculating a susceptible substrate with the CAV,
- b. propagating the virus, and
- c. harvesting CAV containing material, wherein the CAV is an isolated chicken anaemia virus (CAV), wherein the virus is neutralized by a reference sample comprising monoclonal antibody R2 secreted by a hybridoma cell line, having the identifying characteristics of a sample deposited at the ECACC under accession no. 00020304 and the virus is not a chicken anemia agent (CAA) virus attenuated by passaging wild type CAA virus in embryonated chicken eggs, wherein the virus induces lesions in chicken embryos, and wherein the antibody titre of the reference sample is at least 5 (log 2) per 50 μl when examined against 300–1000 TCID5 per 50 μl of the CAV.
Dependencies are inferred from the claim text.