External addition of pulses to fluid channels of body to release or suppress endothelial mediators and to determine effectiveness of such intervention
AssigneeNon-Invasive Monitoring Systems, Inc.
InventorsMarvin A. Sackner, D. Michael Inman
Life of this patent
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Abstract
Methods of medical treatment and diagnosis using mediators released by endothelial cells stimulated by external addition of pulses to the circulation are disclosed. The external pulses produce circumferential shear stress in body fluid channels that subsequently stimulates the endothelial cells to produce mediators that become available for therapeutic and diagnostic purposes. The preferred means of adding external pulses is the mechanical inducement of periodic acceleration of the body or parts of the body by a reciprocating motion platform.
Claims156
A method of medical treatment for a patient with a body, comprising the steps of:
- providing a periodic acceleration means for periodically accelerating one of the body and at least one part thereof to externally and non-invasively add a pulse to the body's fluid filled channels over the body's own pulse;
- and
- treating a disease, condition, or injury of the patient that is treatable by at least one endothelial released mediator by adding pulses, using the periodic acceleration means, to the body's fluid filled channels over the body's own pulse, thereby stimulating endothelial release of beneficial mediators and suppressing non-beneficial mediators;
- wherein the periodic acceleration means comprises a reciprocating movement platform which periodically accelerates the one of the body and at least one part thereof in a headwards-footwards direction at a frequency between about 1 Hz and about 6 Hz.
A method of medical treatment for a patient with a body, comprising the steps of:
- providing a pulse means for externally and non-invasively pulsing one of the body and at least one part thereof;
- and
- treating a disease, condition, or injury of the patient that is treatable by at least one endothelial released mediator by adding pulses, using the pulse means, to the body's fluid filled channels over the body's own pulse, said added pulses not being synchronized with the body's own pulse, thereby stimulating endothelial release of beneficial mediators and suppressing non-beneficial mediators;
- wherein the periodic acceleration means comprises a reciprocating movement platform which periodically accelerates the one of the body and at least one part thereof in a headwards-footwards direction at a frequency between about 1 Hz and about 6 Hz.
A method of medical diagnosis for a subject with a body, comprising the steps of:
- providing a periodic acceleration means for periodically accelerating one of the body and at least one part thereof;
- treating a disease, condition, or injury of the patient that is treatable by at least one endothelial released mediator by adding pulses, using the periodic acceleration means, to the body's fluid filled channels over the body's own pulse to thereby add pulses over the body's own pulse to the body's fluid filled channels;
- and
- testing a physiological response of the subject either during or immediately after the step of adding pulses, using the periodic acceleration means, to the body's fluid filled channels over the body's own pulse;
- wherein the periodic acceleration means comprises a reciprocating movement platform which periodically accelerates the one of the body and at least one part thereof in a headwards-footwards direction at a frequency between about 1 Hz and about 6 Hz.
Dependencies are inferred from the claim text.