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AssigneesCornell Research Foundation, Inc., The United States of America as represented by the Department of Health and Human Services
InventorsFred W. Scott, Christopher K. Ngichabe, Liangbiao Hu, Joseph J. Esposito
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The present invention relates to multivalent recombinant raccoon poxviruses, containing more than one exogenous gene inserted into either the thymidine kinase gene, the hemagglutinin gene, or a combination thereof. Disclosed is the use of the multivalent recombinant raccoon poxviruses as vaccines to immunize felines against subsequent challenge by feline pathogens. Also disclosed is a method of making a multivalent recombinant raccoon poxvirus by a recombination process involving the construction of an insertion vector into which the exogenous genes are inserted, and flanking the inserted genes are sequences which can recombine into the raccoon poxvirus thymidine kinase gene, or the hemagglutinin gene, or a combination thereof; introducing both the insertion vector containing the exogenous genes, and raccoon poxvirus into susceptible host cells; and selecting the recombinant raccoon poxvirus from the resultant plaques.
A multivalent recombinant raccoon poxvirus which can infect and replicate in feline cells, and contains more than one exogenous gene inserted into a region consisting of a thymidine kinase gene of the raccoon poxvirus genome which is non-essential for viral replication, wherein:
A method of vaccinating a feline against feline pathogens, said method comprises administering to the feline a prophylactically effective amount of a multivalent recombinant raccoon poxvirus which can infect and replicate in feline cells, and contains more than one exogenous gene inserted into a region consisting of a thymidine kinase gene of the raccoon poxvirus genome which is non-essential for viral replication, wherein:
Dependencies are inferred from the claim text.