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US 7,083,787 B2Granted
Yeast-dendritic cell vaccines and uses thereof
AssigneesGlobeImmune, Inc., The Regents of the University of Colorado
InventorsRichard C. Duke, Donald Bellgrau, Alex Franzusoff, Cara C. Wilson
Life of this patent
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Abstract
Disclosed is a vaccine that includes a dendritic cell loaded with a yeast vehicle and antigen. Also disclosed are methods of making the vaccine and using the vaccine to elicit cellular and humoral immune responses in a mammal. Additionally, a method to elicit an immune response by administration of a yeast vehicle and an antigen that is not complexed to the yeast vehicle is disclosed.
Claims17
An immunogenic composition, comprising:
- a) an isolated dendritic cell;
- b) a yeast vehicle selected from the group consisting of:
- a whole yeast, a yeast spheroplast, a yeast cytoplast, a yeast ghost, and a subcellular yeast particle;
- and,
- c) at least one immunogen that is heterologous to the yeast vehicle and that is not expressed by or loaded into the yeast vehicle;
- wherein said dendritic cell has been loaded intracellularly with said yeast vehicle and said at least one immunogen.
3 more elements
A method to produce an immunogenic composition, comprising loading a dendritic cell intracellularly with:
- a) a yeast vehicle selected from the group consisting of:
- a whole yeast, a yeast spheroplast, a yeast cytoplast, a yeast ghost, and a subcellular yeast particle;
- and,
- b) at least one immunogen that is heterologous to said yeast vehicle and that is not expressed by or loaded into the yeast vehicle.
1 more element
Dependencies are inferred from the claim text.