Rhabdoviruses with reengineered coats
AssigneeYale University
InventorsJohn K. Rose, Matthias Schnell, E. Erik Johnson
Life of this patent
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Abstract
Replication-competent recombinant rhabdoviruses that lack a functional glycoprotein gene and express at least one foreign polypeptide such as a celluar receptor for another virus in their viral envelopes are useful in the treatment of pathogenic viruses. In one embodiment, a recombinant vesicular stomatitis virus (VSV) lacking its glycoprotein (G) gene and expressing instead the HIV receptor and a coreceptor is employed in a method for treating persons infected with HIV. The recombinant virus is defective for entry into normal cells but is able to control HIV infection in a T cell line by replicating in, and killing, HIV-infected cells.
Claims9
A replication-competent recombinant rhabdovirus whose genome lacks a functional rhabdoviral glycoprotein G gene and encodes at least one foreign polypeptide such that the foreign polypeptide is expressed in the viral envelope of said recombinant rhabdovirus.
A replication-competent recombinant vesicular stomatitis virus whose genome lacks a functional vesicular stomatitis virus glycoprotein G gene and which virus encodes at least one HIV receptor and at least one HIV co-receptor such that the HIV receptor and HIV co-receptor are expressed in the viral envelope of said recombinant vesicular stomatitis virus.
Dependencies are inferred from the claim text.