Methods for manipulating moieties in microfluidic systems
AssigneeAviva Biosciences Corporation
InventorsXiaobo Wang, Lei Wu, Jing Cheng, Weiping Yang, Junquan Xu
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Abstract
This invention relates generally to the field of moiety or molecule manipulation in a chip format. In particular, the invention provides a method for manipulating a moiety in a microfluidic application, which method comprises: a) coupling a moiety to be manipulated onto surface of a binding partner of said moiety to form a moiety-binding partner complex; and b) manipulating said moiety-binding partner complex with a physical force in a chip format, wherein said manipulation is effected through a combination of a structure that is external to said chip and a structure that is built-in in said chip, thereby said moiety is manipulated.
Claims46
A method for manipulating a moiety in a microfluidic application, which method comprises:
- a) coupling a moiety to be manipulated onto a surface of a binding partner of said moiety to form a moiety-binding partner complex;
- and
- b) manipulating said moiety-binding partner complex with a physical force in a microfluidic application chip format, wherein said manipulation is effected through a combination of a signal source that is external to said chip and a structure that is built into or on said chip, thereby said moiety is manipulated, and wherein said moiety is not directly manipulatable by an acoustic force and the moiety-binding partner complex is manipulated by an acoustic force.
A kit for manipulating a moiety in a microfluidic application, which kit comprises:
- a) a binding partner onto the surface of which a moiety to be manipulated can be coupled to form a moiety-binding partner complex;
- b) means for coupling said moiety onto the surface of said binding partner;
- and
- c) a chip on which said moiety-binding partner complex can be manipulated with a physical force that is effected through a combination of a signal source that is external to said chip and a structure that is built into or on said chip, and wherein said moiety is not directly manipulatable by an acoustic force and the moiety-binding partner complex is manipulated by an acoustic force.
Dependencies are inferred from the claim text.