# US 7,078,375 B1 · Diabetes-mediating proteins and therapeutic uses thereof

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- Number: US 7,078,375 B1
- Document ID: US7078375B1
- Status: Granted
- Kind: B1
- Application number: 09/297,040
- Filed: 1997-10-24
- Granted: 2006-07-18
- Earliest claimed: 1996-10-25
- Inventors: Peter Mose Larsen; Stephen J. Fey; Jorn Nerup; Allan E. Karlsen; Ulla Bjerre Christensen; Flemming Pociot; Henrik U. Andersen
- Web page: https://patentgrep.com/patent/US7078375B1

## CPC

- C07K 14/47: from mammals
- C07K: PEPTIDES (peptides in foodstuffs A23; obtaining protein compositions for foodstuffs, working-up proteins for foodstuffs A23J; preparations for medicinal purposes A61K; peptides containing beta-lactam rings C07D; cyclic dipeptides not having in their molecule any other peptide link than those which form their ring, e.g. piperazine-2,5-diones, C07D; ergot alkaloids of the cyclic peptide type C07D519/02; macromolecular compounds having statistically distributed amino acid units in their molecules, i.e. when the preparation does not provide for a specific; but for a random sequence of the amino acid units, homopolyamides and block copolyamides derived from amino acids C08G69/00; macromolecular products derived from proteins C08H1/00; preparation of glue or gelatine C09H; single cell proteins, enzymes C12N; genetic engineering processes for obtaining peptides C12N15/00; compositions for measuring or testing processes involving enzymes C12Q; investigation or analysis of biological material G01N33/00)

## Abstract

Provided are protective and deleterious diabetes-mediating proteins and polynucleotides encoding same, transgenic animals expressing a diabetes-mediating protein, drug screening methods for identifying a test compound capable of altering the expression of a diabetes-mediating protein, and methods of preventing or ameliorating diabetes by administering a compound capable of altering the expression of a diabetes-mediating protein.

## Claims

### Claim 1

A method for ameliorating the symptoms of diabetes in a subject having diabetes comprising administering to said subject a therapeutically effective amount of a protein comprising human galectin-3 of SEQ ID NO:4, wherein said protein is a protective diabetes-mediating protein that ameliorates symptoms of diabetes in said subject.

### Claim 2 (depends on 1)

The method according to claim 1, wherein said subject is a human.

### Claim 3 (depends on 1)

The method according to claim 1, wherein said diabetes is insulin-dependent diabetes mellitus.