Fluorescent probe for zinc
AssigneesDaiichi Pure Chemical Co., Ltd., Tetsuo Nagano
InventorsTetsuo Nagano, Kazuya Kikuchi, Tomoya Hirano
Life of this patent
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Abstract
A compound represented by general formula (IA) or a salt thereof useful as a fluorescent probe for zinc: wherein R1 and R2 represent a hydrogen atom or a group represented by formula (A), wherein X1, X2, X3, and X4 represent a hydrogen atom, an alkyl group, a 2-pyridylmethyl group, or a protective group for an amino group, and m and n represent 0 or 1, provided that R1 and R2 do not simultaneously represent hydrogen atoms; R3 and R4 represent a hydrogen atom or a halogen atom; and R5 and R6 represent a hydrogen atom, an alkylcarbonyl group, or an alkylcarbonyloxymethyl group, and R7 represents a hydrogen atom or an alkyl group
Claims19
A compound represented by general formula (IA) or a salt thereof:
- wherein R1 and R2 independently represent a hydrogen atom or a group represented by formula (A):
- wherein X1, X2, X3, and X4 independently represent a hydrogen atom, an alkyl group, a 2-pyridylmethyl group, or a protective group for an amino group, and m and n independently represent 0 or 1 and at least one of m and n is 1, provided that R1 and R2 do not simultaneously represent hydrogen atoms;
- R3 and R4 independently represent a hydrogen atom or a halogen atom;
- and R5 and R6 independently represent a hydrogen atom, an alkylcarbonyl group, or an alkylcarbonyloxymethyl group.
A compound represented by general formula (IIIA) or a salt thereof:
- wherein R21 and R22 independently represent a hydrogen atom or a group represented by formula (B):
- wherein X11, X12, X13, and X14 independently represent a hydrogen atom, an alkyl group, a 2-pyridylmethyl group, or a protective group for an amino group, and p and q are independently 0 or 1 and at least one of p and q is 1, provided that R21 and R22 do not simultaneously represent hydrogen atoms;
- Y represents —CO—NH— or —NH—CO—;
- R23 and R24 independently represent a hydrogen atom or a halogen atom;
- and R25 and R26 independently represent a hydrogen atom, an alkylcarbonyl group, or an alkylcarbonyloxymethyl group.
A compound represented by general formula (IA) or a salt thereof:
- wherein R1 and R2 independently represent a hydrogen atom or a group represented by formula (A):
- wherein X1, X2, X3, and X4 independently represent a hydrogen atom, an alkyl group, a 2-pyridylmethyl group, or a protective group for an amino group, and m and n independently represent 0 or 1;
- one of R1 and R2 is hydrogen, and the other of R1 and R2 is represented by formula (A) wherein X1 and X2 are 2-pyridylmethyl groups;
- R3 and R4 independently represent a hydrogen atom or a halogen atom;
- and R5 and R6 independently represent a hydrogen atom, an alkylcarbonyl group, or an alkylcarbonyloxymethyl group.
A compound represented by general formula (IIIA) or a salt thereof:
- wherein R21 and R22 independently represent a hydrogen atom or a group represented by formula (B):
- wherein X11, X12, X13, and X14 independently represent a hydrogen atom, an alkyl group, a 2-pyridylmethyl group, or a protective group for an amino group, and p and q are independently 0 or 1, provided that R21 and R22 do not simultaneously represent hydrogen atoms;
- Y represents —CO—NH— or —NH—CO—;
- R23 and R24 independently represent a hydrogen atom or a halogen atom;
- and R25 and R26 are hydrogen atoms.
Dependencies are inferred from the claim text.