A method of treating and processing alkaloid, oil and protein-containing lupine seeds for extraction of products from the lupine seeds by targeted fractionation, so that comminuted lupine seeds are de-oiled by introducing a solvent and a residue is depleted of substances soluble in an acid range, by adding acids, comprising comminuting and/or shaping the lupine seeds to form discoid flakes so that after pre-crushing of the shelled or non-shelled seeds, comminution of the seeds is carried out by a cooled flocculating roller, so as to maintain the seeds during comminution at a temperature below a temperature at which denaturation of the seeds occurs and heating the seeds by an indirect supply of heat substantially with exclusion of water, and performing after de-oiling depletion of the flakes of substances soluble in the acid range, by aqueous extraction, with a refined product of a reduced alkaloid level and an aqueous extract being obtained.