Back to results
US 7,073,510 B2Granted
Photochemical tissue bonding
AssigneeThe General Hospital Corporation
InventorsRobert W. Redmond, Irene E. Kochevar
Life of this patent
Estimating the term…
Abstract
Photochemical tissue bonding methods include the application of a photosensitizer to a tissue and/or tissue graft, followed by irradiation with electromagnetic energy to produce a tissue seal. The methods are useful for tissue adhesion, such as in wound closure, tissue grafting, skin grafting, musculoskeletal tissue repair, ligament or tendon repair and corneal repair.
Claims30
A method for repairing a skin lesion in vivo in a subject, comprising:
- contacting a skin lesion, a tissue comprising a skin graft and Rose Bengal (RB) at a concentration of less than 1.0% weight per volume to form a skin tissue-RB complex;
- and
- applying electromagnetic energy having a wavelength of at least 488 nm to the skin tissue-RB complex in a manner effective to bond the complex,
- wherein the skin lesion and/or graft is not contacted with an exogenous cross-linkable substrate,
- thereby promoting a partial or complete repair of the skin lesion.
2 more elements
A method for bonding musculoskeletal tissue with a tissue seal, comprising:
- contacting a first musculoskeletal tissue, a second musculoskeletal tissue, and rose bengal at a concentration of less than 1.0% weight per volume to form a musculoskeletal tissue-photosensitizer complex;
- and
- applying electromagnetic energy having a wavelength of at least 488 nm to the musculoskeletal tissue-photosensitizer complex in a manner effective to bond the musculoskeletal tissues,
- wherein the musculoskeletal tissues are not contacted with an exogenous cross-linkable substrate,
- thereby creating a tissue seal between the first and second tissues.
2 more elements
Dependencies are inferred from the claim text.