Apparatus and methods of brain shift compensation and applications of the same
AssigneeVanderbilt University
InventorsMichael I. Miga, Prashanth Dumpuri, Chun-Cheng R. Chen
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Abstract
A method of compensation for intra-operative brain shift of a living subject. In one embodiment, the method includes the steps of pro-operatively acquiring brain images of the living subject, constructing a statistical atlas of brain displacements of the living subject from the pro-operatively acquired brain images, intra-operatively measuring brain displacements of the living subject, deriving an intra-operative displacement atlas from the intra-operatively measured brain displacements and the statistical atlas, obtaining intra-operative brain shift at least from the intra-operative displacement atlas, and compensating for the intra-operative brain shift.
Claims33
A method of compensation for intra-operative brain shift of a living subject, comprising the steps of:
- a. pro-operatively acquiring brain images of the living subject;
- b. constructing a statistical atlas, [E], of brain displacements of the living subject from the pro-operatively acquired brain images, wherein [E] comprises a distribution of brain shift solutions corresponding to a pre-operative surgical plan and is in the form of an n×m matrix with n, m being integers;
- c. intra-operatively measuring brain displacements, {f}, of the living subject, wherein {f} is in the form of a n×1 matrix;
- d. deriving an intra-operative displacement atlas, [Xf], from the intra-operatively measured brain displacements {f} and the statistical atlas [E];
- e. obtaining intra-operative brain shift at least from the intra-operative displacement atlas [Xf];
- and
- f. compensating for the intra-operative brain shift.
A system of compensation for intra-operative brain shift of a living subject, comprising:
- a. an imaging acquiring device for pro-operatively acquiring brain images of the living subject;
- b. a scanning device for intra-operatively measuring brain displacements of the living subject;
- and
- c. at least one computer coupled with the image acquiring device and the scanning device and adapted for performing the steps of:
- i). constructing a statistical atlas of brain displacements of the living subject from the pro-operatively acquired brain images, wherein the statistical atlas comprises a distribution of brain shift solutions corresponding to a pre-operative surgical plan;
- ii). deriving an intra-operative displacement atlas from the intra-operatively measured brain displacements and the statistical atlas;
- iii). obtaining intra-operative brain shift at least from the intra-operative displacement atlas;
- and
- iv). compensating for the intra-operative brain shift.
A method of compensation for intra-operative brain shift of a living subject, comprising the steps of:
- a. constructing a statistical atlas from pre-operatively acquired brain images of the living subject, wherein the statistical atlas comprises a distribution of brain shift solutions corresponding to a pre-operative surgical plan;
- b. calculating brain displacements of the living subject from the statistical atlas for a given set of the living subject's orientation and amount of cerebrospinal fluid drainage;
- c. intra-operatively measuring brain displacements of the living subject;
- d. obtaining the intra-operative brain shift from the calculated brain displacements and the measured brain displacements;
- and
- e. compensating for the intra-operative brain shift.
Dependencies are inferred from the claim text.