Process for the preparation of 1-(aminomethyl) cyclohexaneacetic acid
AssigneeISP Investments Inc.
InventorsSatish C. Nigam, Krishnamurthy Nacharaju, Christophe Buron
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Abstract
A method of producing gabapentin (1-amino-methyl)-1-cyclohexaneacetic acid) from its hydrochloric salt in an anhydrous medium, the method consisting of: dissolving gabapentin hydrochloride in a non-aqueous organic solvent in which gabapentin is insoluble to obtain a solution of gabapentin hydrochloride; adding an epoxide to the solution to remove the chloride ions thereby precipitating gabapentin out of the solution as a white solid; recovering the white solid by filtration; and drying the white solid.
Claims8
A process for the preparation of gabapentin from gabapentin hydrochloride comprising:
- dissolving gabapentin hydrochloride in a non-aqueous organic solvent to obtain a solution;
- adding an epoxide to the solution to remove the chloride ions from the solution thereby precipitating gabapentin out of the solution as a white solid in its free amino acid form;
- recovering the white solid by filtration;
- and
- drying the white solid until no loss of weight is observed.
Dependencies are inferred from the claim text.