Purification method of N-(1(S)-ethoxycarbonyl-3-phenylpropyl)-L-alanine
AssigneeKanaka Corporation
InventorsAkira Matsumoto, Michio Nomura, Yoshikazu Kogame, Yasuyoshi Ueda
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Abstract
The present invention is to provide a purification method of obtaining N-(1(S)-ethoxycarbonyl-3-phenylpropyl)-L-alanine of high quality in good yield with high productivity, which is accordingly suited for commercial scale application. An impurity-contaminated N-(1(S)-ethoxycarbonyl-3-phenylpropyl)-L-alanine is crystallized from a mixed solvent of alcohol and water in a volume ratio of alcohol/water being 1 to 20 to remove a contaminating impurity into a mother liquor and give crystals of N-(1(S)-ethoxycarbonyl-3-phenylpropyl)-L-alanine.
Claims22
A purification method of N-(1(S)-ethoxycarbonyl-3-phenylpropyl)-L-alanine represented by the formula (1)
- which comprises crystallizing impurity-contaminated N-(1(S)-ethoxycarbonyl-3-phenylpropyl)-L-alanine from a mixed solvent of alcohol and water in a volume ratio of alcohol/water being 1/1 to 20/1 to remove a contaminating impurity into a mother liquor and give crystals of N-(1(S)-ethoxycarbonyl-3-phenylpropyl)-L-alanine,
- said alcohol being a monohydric alcohol of 1 to 12 carbon atoms.
Dependencies are inferred from the claim text.