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US 7,071,339 B2Granted
Process for preparing functionalized γ-butyrolactones from mucohalic acid
AssigneeWarner-Lambert Company
InventorsDaniel Belmont, Ji Zhang
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Abstract
A process for preparing functionalized γ-butyrolactones 3 and various biologically active compounds using mucohalic acid 1 and halide 2 in the presence of indium is disclosed, wherein X, Y, R1, R2, and R3 may have any of the meanings defined herein
Claims30
A process for preparing functionalized butyrolactones of formula
- wherein X is Cl or Br;
- R1, R2, and R3 are each independently H, halo, aryl, (C1–C6)alkoxycarbonyl, (C1–C6)alkanoyl, (C1–C6 alkyl), halo(C1–C6 alkyl), heteroaryl(C1–C6)alkyl or aryl (C1–C6 alkyl);
- and
- “- - - ” is a bond or is absent, provided that when “- - - ” is a bond, R1 and R2 are absent;
- comprising:
- (a) contacting mucohalic acid 1
- wherein X is as defined above;
- with halide 2
- wherein Y is Cl, Br, or I;
- R1, R2, and R3 are as defined above;
- and
- “- - - ” is as defined above;
- a metal selected from indium, tin or zinc;
- and
- a catalytic amount of ammonium chloride in a solvent to form the compound of formula I.
12 more elements
Dependencies are inferred from the claim text.