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US 7,071,337 B2Granted
Benzoimidazole derivatives useful as antiproliferative agents
AssigneePfizer Inc.
InventorsJohn C. Kath, Joseph P. Lyssikatos, Huifen Faye Wang
Life of this patent
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Abstract
The invention relates to compounds of the formula 1 and to pharmaceutically acceptable salts, prodrugs and solvates thereof, wherein R1, R2, R3, and R4 are as defined herein. The invention also relates to methods of treating abnormal cell growth, such as cancer, in mammals by administering the compounds of formula 1 and to pharmaceutical compositions for treating such disorders which contain the compounds of formula 1. The invention also relates to methods of preparing the compounds of formula 1.
Claims9
A compound selected from the group consisting of:
- (±)-1-{2-[5-(Tetrahydro-furan-3-yloxy)-benzoimidazol-1-yl]-quinolin-8-yl}-piperidin-4-ylamine;
- 1-{2-[5-(3-Methyl-oxetan-3-ylmethoxy)-benzoimidazol-1-yl]-quinolin-8-yl}-piperidin-4-ylamine;
- 1-{2-[5-(Tetrahydro-pyran-4-yloxy)-benzoimidazol-1-yl]-quinolin-8-yl}-piperidin-4-ylamine;
- and the pharmaceutically acceptable salts of the foregoing compounds.
1 more element
Dependencies are inferred from the claim text.