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US 7,071,336 B2Granted
Process for manufacturing opioid analgesics
AssigneeAcura Pharmaceuticals, Inc.
InventorsCharles Auxilium Francis, Zhaiwei Lin, Christopher Arne Kaldahl, Kazimierz Grzegorz Antczak, Vijai Kumar
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Abstract
Oxycodone is manufactured in high yields and with a high purity using a composition including a thebaine component into 14-hydroxycodeinone and then reduction of 14-hydroxycodeinone to oxycodone.
Claims21
A process for the preparation of oxycodone, which comprises the steps of:
- (a) oxidation of a composition including a thebaine component into 14-hydroxycodeinone;
- and
- (b) reduction of 14-hydroxycodeinone to oxycodone;
- wherein the composition including a thebaine component comprises a concentrate of poppy straw.
1 more element
For the preparation of an oxycodone acid salt, which comprises the steps of:
- a) oxidation of a composition including a thebaine component into 14-hydroxycodeinone;
- b) reduction of 14-hydroxycodeinone to oxycodone;
- c)transformation of the oxycodone to an acid salt.
Dependencies are inferred from the claim text.