Epidermal differentiation factor
AssigneesUniversity of Antwerp, Human Genome Sciences, Inc.
InventorsJian Ni, Ping Feng, Patrick J. Dillon, Reiner L. Gentz, Joseph Merregaert, Patrick Smits
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Abstract
A human epidermal differentiation factor polypeptide and DNA (RNA) encoding such polypeptide and procedure for producing such polypeptide by recombinant techniques is disclosed. Also disclosed are methods for utilizing such polypeptide for treating and/or preventing skin diseases. Diagnostic assays for detecting mutations in a nucleic acid sequence encoding a polypeptide of the present invention and for detecting altered levels of the polypeptide of the present invention are also disclosed.
Claims27
An isolated polypeptide, selected from the group consisting of:
- (a) a polypeptide comprising amino acids −19 to 396 of SEQ ID NO:2;
- (b) a polypeptide comprising amino acids 1 to 396 of sequence of SEQ ID NO:2;
- (c) a polypeptide comprising the full-length Epidermal Differentiation Factor (EDF) polypeptide encoded by the human cDNA in ATCC™ Deposit No. 97407;
- (d) a polypeptide comprising the mature form of the EDF polypeptide encoded by the human cDNA in ATCC™ Deposit No. 97407,
- wherein said polypeptide is glycosylated.
An isolated polypeptide selected from the group consisting of:
- (a) a polypeptide consisting of amino acids −19 to 396 of SEQ ID NO:2;
- (b) a polypeptide consisting of amino acids 1 to 396 of sequence of SEQ ID NO:2;
- (c) a polypeptide consisting of the full-length EDF polypeptide encoded by the human cDNA in ATCC™ Deposit No. 97407;
- (d) a polypeptide consisting of the mature form of the EDF polypeptide encoded by the human cDNA in ATCC™ Deposit No. 97407.
An isolated polypeptide at least 95% identical to a polypeptide selected from the group consisting of:
- (a) a polypeptide comprising amino acids −19 to 396 of SEQ ID NO:2;
- (b) a polypeptide comprising amino acids 1 to 396 of sequence of SEQ ID No:2;
- (c) a polypeptide comprising the full-length EDF polypeptide encoded by the human cDNA in ATCC™ Deposit No. 97407;
- (d) a polypeptide comprising the mature form of the EDF polypeptide encoded by the human cDNA in ATCC™. Deposit No. 97407,
- wherein said polypeptide promotes bone formation or stimulates hematopoietic cell growth.
Dependencies are inferred from the claim text.