Antibodies having specificity for 2′-C-allyl nucleic acids
AssigneeSirna Therapeutics, Inc.
InventorsSusan Radka, Leonid Beigelman, Haeberli Peter
Life of this patent
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Abstract
The present invention relates to antibodies, antibody conjugates, and compositions thereof, methods of antibody synthesis, and applications of antibodies useful for detecting the presence of nucleic acid molecules in vivo, such as in a clinical setting. The antibodies of the invention are also useful as screening agents which allow the selection of candidate therapeutic molecules for optimum bioavailability and/or activity, and as delivery agents for cell and tissue specific delivery of nucleic acid molecules.
Claims16
An isolated monoclonal antibody having binding affinity for a 2′-deoxy-2′-C-allyl Uridine nucleoside or 2′-deoxy-2′-C-allyl Uridine nucleotide of a nucleic acid molecule.
An isolated monoclonal antibody having binding affinity for a 2′-deoxy-2′-C-allyl Uridine nucleoside or 2′-deoxy-2′-C-allyl Uridine nucleotide of a nucleic acid molecule comprising SEQ ID NO:
- 1.
An isolated monoclonal antibody having binding affinity for a 2′-deoxy-2′-C-allyl Uridine nucleoside or 2′-deoxy-2′-C-allyl Uridine nucleotide of a nucleic acid molecule comprising SEQ ID NO:
- 3.
An isolated monoclonal antibody having binding affinity for a 2′-deoxy-2′-C-allyl Uridine nucleoside or 2′-deoxy-2′-C-allyl Uridine nucleotide of a nucleic acid molecule comprising SEQ ID NO:
- 16.
An isolated monoclonal antibody having binding affinity for a 2′-deoxy-2′-C-allyl Uridine nucleoside or 2′-deoxy-2′-C-allyl Uridine nucleotide of a nucleic acid molecule comprising SEQ ID NO:
- 17.
Dependencies are inferred from the claim text.