Antibodies to breast specific gene 1
AssigneeHuman Genome Sciences, Inc.
InventorsHongjun Ji, Craig A. Rosen
Life of this patent
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Abstract
Human breast specific gene polypeptides and DNA (RNA) encoding such polypeptides and a procedure for producing such polypeptides by recombinant techniques is disclosed. Also disclosed are methods for utilizing such polynucleotides or polypeptides as a diagnostic marker for breast cancer and as an agent to determine if breast cancer has metastasized. Also disclosed are antibodies specific to the breast specific gene polypeptides which may be used to target cancer cells and be used as part of a breast cancer vaccine. Methods of screening for antagonists for the polypeptide and therapeutic uses thereof are also disclosed.
Claims16
An isolated antibody or fragment thereof that specifically binds to a protein whose amino acid sequence consists of the amino acid sequence of the BSG1 polypeptide encoded by the BSG1 cDNA contained in ATCC Deposit No. 97175,
- wherein said protein is overexpressed in breast cancer.
An isolated antibody or fragment thereof that specifically binds a BSG1 protein purified from a cell culture wherein said protein is encoded by a the BSG1 cDNA contained ATCC Deposit No. 97175.
Dependencies are inferred from the claim text.