Peptide and polypeptide inhibitors of complement C1s
AssigneeZymoGenetics, Inc.
InventorsRobert R. West, Paul O. Sheppard, Brian A. Fox
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Abstract
The complement system plays an important role in providing resistance to infections and in the pathogenesis of tissue injury. Yet an inappropriate activation of complement can result in a variety of disorders. The present invention provides C1s catalytic site-directed moieties, C1s exosite binding moieties, and bivalent polypeptide inhibitors comprising such moieties, which can be used to treat conditions characterized by inappropriate complement activation.
Claims3
A peptide or polypeptide that inhibits complement C1s, wherein the peptide or polypeptide comprises the amino acid sequence “CRLGC” (amino acid residues 64 to 68 of SEQ ID NO:1), wherein the peptide or polypeptide consists of five to thirty amino acid residues of SEQ ID NO:
- 1.
Dependencies are inferred from the claim text.