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US 7,071,294 B1Granted
Tumor antigen protein art-1 and tumor antigen peptide thereof
AssigneeGreen Peptide Co., Ltd.
InventorsKyogo Itoh, Shinya Gomi
Life of this patent
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Abstract
A novel tumor antigen protein and gene therefor, tumor antigen peptides derived from said tumor antigen protein or derivatives thereof as well as medicaments, prophylactics, or diagnostics for tumors using such tumor substances in vivo or in vitro are provided.
Claims10
An isolated tumor antigen peptide consisting of 8 to 14 amino acids that is a fragment of the amino acid sequence of SEQ ID NO:
- 1 and that binds to an HLA antigen and is recognized by cytotoxic T lymphocytes.
An isolated tumor antigen peptide consisting of 8 to 14 amino acids that is a fragment of the amino acid sequence of SEQ ID NO:
- 1, which fragment comprises a sequence selected from an amino acid sequence shown in any one of SEQ ID NOs:
- 3–18, or an isolated tumor antigen peptide consisting of 8 to 14 amino acids that is a fragment of the amino acid sequence of SEQ ID NO:
- 1, which comprises a sequence selected from an amino acid sequence shown in any one of SEQ ID NOs:
- 3–18 wherein the amino acid residue at position 2 is substituted by tyrosine, phenylalanine, methionine, or tryptophan, and/or the C-terminus is substituted by phenylalanine, leucine, isoleucine, tryptophan, or methionine, and which binds to an HLA antigen and is recognized by cytotoxic T lymphocytes.
1 more element
Dependencies are inferred from the claim text.