Therapeutic use of D-methionine to reduce the toxicity of noise
AssigneeBoard of Trustees of Southern Illinois University
InventorKathleen C. M. Cambpell
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Abstract
Methods of preventing or reducing hearing or balance loss and damage to ear cells in patients who have been exposed to toxic levels of noise are provided. These methods comprise administering an effective amount of a methionine protective agent, such as D-methionine, prior to, simultaneously with, or subsequently to exposure to noise. Combinations of these time periods can also be employed.
Claims38
A method for preventing or treating ototoxicity in a patient exposed to noise for a time and at an intensity sufficient to result in ototoxicity, comprising administering to said patient an anti-ototoxic effective amount of an otoprotective agent comprising methionine.
The method for preventing or treating ototoxicity in a patient exposed to noise for a time and at an intensity sufficient to result in ototoxicity, the method comprising administering to said patient an effective amount of an otoprotective agent comprising D-methionine, L-methionine, D,L-methionine, a combination thereof or a pharmaceutically acceptable salt thereof, the administration of said effective amount of said otoprotective agent resulting in a blood serum level equivalent to that achieved by parenteral administration in the range of from about 10 mg/kg body weight to about 400 mg/kg body weight.
A method for preventing or treating ototoxicity in a patient exposed to noise for a time and at an intensity sufficient to result in ototoxicity, comprising administering to said patient an anti-ototoxic effective amount of an otoprotective agent comprising methionine.
A method for preventing or treating ototoxicity in a patient exposed to noise for a time and at an intensity sufficient to result in ototoxicity, the method comprising administering to said patient an effective amount of an otoprotective agent comprising D-methionine, L-methionine, D,L-methionine, a combination thereof or a pharmaceutically acceptable salt thereof, the administration of said effective amount of said otoprotective agent resulting in a blood serum level equivalent to that achieved by parenteral administration in the range of from about 10 mg/kg body weight to about 400 mg/kg body weight.
Dependencies are inferred from the claim text.