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US 7,071,229 B2Granted
Process for producing corosolic acid
AssigneeTokiwa Phytochemical Co., Ltd.
InventorsHiromitsu Takayama, Mariko Kitajima, Tomoko Ishizuka, Shujiro Seo
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Abstract
This invention provides an improved process for producing corosolic acid starts from ursolic acid, which occurs in plants in relatively large amounts, the method comprising the steps of oxidizing the hydroxyl group at 3-position and utilizing the carbonyl group at 3-position to introduce a hydroxyl group stereospecifically into the 3-oxoursolic acid at the 2α-position adjacent to the hydroxyl group at 3-position.
Claims4
A process for producing corosolic acid or a corosolic acid ester, which comprises the steps of:
- a) oxidizing a compound of formula III:
- where R1 is a hydrogen atom or a C1–C6 alkyl in a solvent to a compound of formula IV:
- where R1 is a hydrogen atom or a C1–C6 alkyl;
- and
- b) reducing the compound of formula IV, in a solvent at a temperature in the range from −50° C. to room temperature, to corosolic acid of formula I:
- where R1 is a hydrogen atom or a C1–C6 alkyl or a corosolic acid ester.
3 more elements
Dependencies are inferred from the claim text.