Preparation and use of 1,5,6,7-tetrahydropyrrolo[3,2-c]pyridine derivatives for treatment of obesity

A compound of Formula (I)

• wherein
• R1 is phenyl optionally substituted with one or more halogen, (C1–C6)alkyl, (C1–C6)alkoxy, (C 1–C6)alkylthio, trifluoromethyl, trifluoromethoxy, carboxyl, amino, cyano, nitro, (C1–C6)alkyl-carbonyl-amino, (C1–C6)alkyl-amino-carbonyl-amino, or phenyl optionally substituted with one or more halogen;
• R2 is a hydrogen,
• halogen,
• (C1–C9)alkyl optionally substituted with (C1–C6)alkoxy, trifluoromethyl, or with one or more fluorine,
• phenyl optionally substituted with one or more halogen, (C1–C6)alkyl, (C2–C8)alkenyl, (C2–C8)alkynyl, (C1–C6)alkoxy, (C1–C6)alkyl-thio, trifluoromethyl, trifluoromethoxy, carboxyl, amino, cyano, nitro, (C1–C6)alkyl-carbonyl-amino, (C1–C6)alkyl-amino-carbonyl-amino, or phenyl,
• or
• a 5- to 10-membered aromatic monocyclic or bicyclic heterocyclic radical optionally substituted with one or more halogen, (C1–C6)alkyl, (C1–C6)alkoxy, trifluoromethyl, trifluoromethoxy, cyano, or nitro;
• R3 is hydrogen, (C1–C6)alkyl, or benzyl;
• X is —C(═O)—;
• R4 is
• hydrogen,
• (C1–C9)alkyl optionally substituted with one or more hydroxy, benzyloxy, (C1–C6)alkoxy, trifluoromethyl, cyano, or fluorine,
• benzyl or phenyl, optionally substituted on the phenyl ring with one or more (C1–C6)alkyl, hydroxy, (C1–C6)alkoxy, trifluoromethyl, cyano, nitro, or halogen,
• piperidin-4-yl, piperidin-3-yl, or pyrrolidin-3-yl, each of which may be optionally substituted on the nitrogen atom of the piperidine or pyrrolidine ring with (C1–C6)alkyl, (C1–C6)hydroxyalkyl, benzyl, or phenyl, in which the benzyl or phenyl group may optionally be substituted on the phenyl ring with one or more halogen, (C1–C6)alkyl, (C1–C6)alkoxy, or trifluoromethyl,
• —NR5R6 in which R5 and R6, taken together with the nitrogen atom to which they are attached, form a 5- to 10-membered saturated or unsaturated heterocyclic radical which is optionally substituted with one or more (C1–C6)alkyl, (C1–C6)alkoxy, hydroxy-substituted (C1–C3)alkyl, (C1–C3)alkoxy-substituted (C1–C3)alkyl, benzyl, phenyl, hydroxy, or fluorine,
• or
• a 5- to 10-membered aromatic monocyclic or bicyclic heterocyclic radical optionally substituted with one or more halogen, (C1–C6)alkyl, (C1–C6)alkoxy, trifluoromethyl, cyano, or nitro;
• and pharmaceutical salts and esters thereof.