Camptothecin analogs having an E-ring ketone

A camptothecin analog having the structure:

• where
• X is NO2, NH2, H, F, Cl, Br, I, COOH, OH, O—C1-6 alkyl, SH, S—C1-6 alkyl, CN, NH—C1-6 alkyl, N(C1-6 alkyl)2, CHO, C1-8 alkyl, N3,
• —Z—(CH2)a—N—((CH2)bOH)2, wherein Z is selected from the group consisting of O, NH and S, and a and b are each independently an integer of 2 or 3,
• —Z—(CH2)a—N—(C1-6 alkyl)2 wherein Z is selected from the group consisting of O, NH and S, and a is an integer of 2 or 3,
• —CH2-L, where L is halogen, +N2, +(OR1)2, +S(R1)2, +N(R1)3, OC(O)R1, OSO2R1, OSO2CF3, OSO2C4F9, C1-6 alkyl-C(═O)—, C4-18 aryl-C(═O)—, C1-6 alkyl-SO2—, perfluoro C1-6 alkyl-SO2— or C4-18 aryl-SO2—, (where each R1 independently is C1-6 alkyl, C4-18 aryl or C4-18 ArC1-6 alkyl);
• or
• —CH2NR2R3, where (a) R2 and R3 are, independently, hydrogen, C1-6 alkyl, C3-7 cycloalkyl, C3-7 cycloalkyl C1-6 alkyl, C2-6 alkenyl, hydroxy C1-6 alkyl, C1-6 alkoxy C1-6 COR4 where R4 is hydrogen, C1-6 alkyl, perhalo C1-6 alkyl, C3-7 cycloalkyl, C3-7 cycloalkyl-C1-6 alkyl, C2-6 alkenyl, hydroxyl-C1-6 alkyl, C1-6-alkoxy, or C1-6 alkoxy-C1-6 alkyl;
• Y is SH, S—C1-6 alkyl, NH—C1-6 alkyl, —CHO, N3,
• —Z—(CH2)a—N—((CH2)bOH)2, wherein Z is selected from the group consisting of O, NH and S, and a and b are each independently an integer of 2 or 3,
• —Z—(CH2)a—N—(C1-6 alkyl)2 wherein Z is selected from the group consisting of O, NH and S, and a is an integer of 2 or 3, or
• —CH2-L, where L is halogen, +N2, +(OR)2, +S(R1)2, +N(R1)3, OC(O)R1, OSO2R1, OSO2CF3, OSO2C4F9, C1-6 alkyl-C(═O)—, C4-18 aryl-C(═O)—, C1-6 alkyl-SO2—, perfluoro C1-6 alkyl-SO2— or C4-18 aryl-SO2—, (where each R1 independently is C1-6 alkyl, C4-18 aryl or C4-18 ArC1-6 alkyl);
• R7is H;
• and
• R13 and R14 are each H or combine to form a double bond;
• and salts thereof.