Compositions and formulations of 9-nitrocamptothecin polymorphs and methods of use therefor
AssigneeSuperGen, Inc.
InventorsSanjeev Redkar, Ashok Gore
Life of this patent
Estimating the term…
Abstract
A polymorphic form of 9-nitrocamptothecin is provided, the polymorph being characterizable as having, by differential scanning calorimetry, no observable endotherm and an exotherm at between 273.6 and 275.6° C., and a solution NMR spectrum with multiplets at 1.7 and 3.7 ppm shifts.
Claims11
9-nitrocamptothecin in crystal form C wherein the crystal form C is characterizable as having, by differential scanning calorimetry, no observable endotherm and an exotherm at between 273.6 and 275.6° C., a solution NMR spectrum with multiplets at 1.7 and 3.7 ppm shifts, and an X-ray powder diffraction pattern with diffraction lines at °2θ values 6.7, 12.5, 14.0 and 23.9 for Cu Kα radiation of wavelength 1.5406 Angstrom.
A pharmaceutical composition in a solid dosage form comprising:
- a powdered pharmaceutical carrier;
- and 9-nitrocamptothecin in crystal form C, wherein the crystal form is characterizable as having, by differential scanning calorimetry, no observable endotherm and an exotherm at between 273.6 and 275.6° C., a solution NMR spectrum with multiplets at 1.7 and 3.7 ppm shifts, and an X-ray powder diffraction pattern with diffraction lines at °2θ values 6.7, 12.5, 14.0 and 23.9 for Cu Kα radiation of wavelength 1.5406 Angstrom.
Dependencies are inferred from the claim text.