Quinoline derivatives

A compound of formula (I):

• wherein A, B, C, D, and T are the same or different from one another and each represents methine or nitrogen, provided that one and only one of them represents nitrogen;
• the bond represented by the following formula:
• - - - - -
• represents a single or double bond;
• Y and Z are the same or different from each other and each represents methine, nitrogen, a group represented by the following formula:
• or a group represented by the following formula:
• provided at least one of them represents nitrogen;
• R1 and R2 are the same or different from each other and each represents hydrogen, halogeno, hydroxy, lower alkylsulfonylaminoalkyl, lower halogenated-alkylsulfonylaminoalkyl, 2-pyrrolidinon-1-yl, 1-hydroxy-1- (methoxypyridyl)methyl, methoxypyridylcarbonyl, 1,3-propanesultum-2-yl, lower hydroxypiperidyl -carbonylalkyl, lower hydroxyalkylamidoalkyl, lower halogenated-alkylamidoalkyl, lower dihalogenatedalkylamidoalkyl, lower hydroxyalkylamidoalkyl, optionally substituted amino, nitro, lower alkyl, lower alkoxy, lower acyl, lower alkoxyalkoxy, cyano, lower alkylsulfonyl, sulfonylamido, hydroxy-lower alkyl, hydroxy-lower alkoxy, lower alkoxycarbonylamino, lower alkylsulfonylamino, N-lower alkylalkylsulfonylamino, lower acylamino, optionally substituted aminoalkyl, optionally N-substituted lower acylaminoalkyl, optionally substituted aryl, optionally substituted arylsulfonylamino, lower alkylsulfonyloxy, hydroxyiminomethyl, (2-pyrrolidonl-yl) methyl, (2-piperidon-1-yl) methyl, optionally substituted heteroaryl, optionally substituted aralkyl, optionally substituted heteroarylalkyl, cycloalkylcarbonylaminoalkyl, optionally substituted ureido, optionally substituted ureido-lower alkyl, succinimido, (succinimido-1-yl)-lower alkyl, amido, optionally substituted carbamoyl, optionally substituted carbamoyl-lower alkyl, optionally substituted thiocarbamoyllower alkyl, formyl, aromatic acyl, heteroarylcarbonyl, halogenated lower alkyl, (2-imidazolidinon -1-yl)methyl, (2,4-imidazolidinedion-3-yl)methyl, (2-oxazolidon3-yl) methyl, (glutarimido-1-yl)methyl, optionally substituted heteroarylhydroxyalkyl, cyano-lower alkyl, 1-hydroxy lower cycloalkyl, (2,4-thiazolidinedion-3-yl)methyl, optionally substituted 4-piperidylmethyl, heteroarylacyl, pyrrolidinylcarbonyl-lower alkyl, optionally substituted aminosulfonylalkyl, carboxy-lower alkyl, or lower alkylamidoalkyl;
• or alternatively optionally substituted heterocycle or alkylenedioxy, provided these rings may be substituted;
• R3 represents hydrogen, halogeno, lower alkyl, hydroxy, hydroxy-lower alkyl, lower alkoxy, formyl, optionally substituted aralkyloxy, hydroxy-lower alkoxy, optionally substituted sulfamoyl, or optionally N-substituted sulfamoyl-lower alkyl;
• R4 represents hydrogen, lower alkyl, hydroxy-lower alkyl, lower alkoxyalkyl, optionally aryl-substituted aryloxyalkyl, or optionally aryl-substituted aralkyloxyalkyl;
• R5 represents lower alkyl, lower acyl, lower alkoxycarbonyl, aromatic acyl, or a group represented by the following formula:
• -Q1-(CH2)s-Q2-R6
• wherein Q1 and Q2 are both single bonds, or one of them is a single bond while the other represents oxygen, carbonyl, a group represented by —NHCO—, a group represented by —NHSO2—, or a group represented by >CH—R7, wherein R7 represents hydroxy, lower alkyl or halogeno:
• s represents 0 or an integer of 1 to 6;
• and
• R6 represents optionally substituted aryl, optionally substituted benzoheteroaryl, 1,4-benzodioxanyl, 1,3-benzodioxolyl, benzothiazolyl, or cyano;
• n represents 1;
• m represents 0 or an integer of 1 to 6;
• and
• p represents an integer of 1 to 3,
• or a pharmacologically acceptable salt thereof.