Gonadotropin-releasing hormone receptor antagonists and methods relating thereto

A compound having the following structure:

• or a stereoisomer or pharmaceutically acceptable salt thereof,
• wherein:
• R1a and R1b are the same or different and independently hydrogen, halogen, C1-4alkyl, or alkoxy;
• R2a and R2b are the same or different and independently hydrogen, halogen, trifluoromethyl, cyano or —SO2CH3;
• R3 is hydrogen or methyl;
• R4 is phenyl or C3-7alkyl;
• R5 and R6 are the same or different and independently hydrogen or C1-4alkyl;
• or
• R5 and the nitrogen to which it is attached taken together with R4 and the carbon to which it is attached form 1,2,3,4-tetrahydroisoquinoline or 2,3-dihydro-1H-isoindole;
• R7 is —COOH or an acid isostere;
• and
• X is —O—(C1-6alkanediyl)- or —O—(C1-6alkanediyl)—O—(C1-6alkanediyl)- wherein each C1-6alkanediyl) is optionally substituted with from 1 to 3 C1-4alkyl groups.