Amine and amide derivatives as ligands for the neuropeptide Y Y5 receptor useful in the treatment of obesity and other disorders

A compound of the formula

• wherein R1 is independently selected from the group consisting of H;
• alkyl;
• substituted alkyl;
• alkoxy;
• halo;
• substituted alkoxy;
• hydroxy;
• trifluoralkyl;
• nitro;
• amino;
• alkylamino;
• cycloalkylamino;
• cyano;
• carboxy;
• cycloalkyl;
• phenyl;
• and substituted phenyl;
• R2 is pyridyl;
• B1 is hydrogen;
• B2 is hydrogen;
• or B1 and/or B2 are methylene and joined together to form a five or six membered ring;
• Y is methylene or carbonyl;
• L is selected from the group consisting of
• R3 is independently selected from the group consisting of C1-6 alkyl;
• substituted C1-8alkyl;
• cycloalkyl;
• substituted cycloalkyl;
• naphthyl;
• substituted naphthyl;
• heteroaryl;
• and substituted heteroaryl;
• R4 is independently selected from the group consisting of hydrogen;
• C1-8alkyl;
• C1-8alkoxy;
• substitued C1-8alkoxy;
• hydroxy;
• halogen;
• cyano;
• nitro;
• amino;
• C1-8alkylamino;
• and C1-8dialkylamino;
• R5 is independently selected from the group consisting of hydrogen;
• C1-8alkyl;
• C1-8alkylcarbonyl;
• aroyl;
• carbamoyl;
• amidino;
• C1-8alkyl;
• C1-8alkylaminocarbonyl;
• (arylamino)carbonyl;
• and arylC1-8alkylcarbonyl;
• R6 is independently selected from hydrogen and C1-8alkyl;
• n is 1–2;
• m is 0–3;
• p is 1–3;
• and
• q is 1–3;
• provided that when L is (N-methylene)piperazin-4-yl, then Z is phenyl or naphthyl;
• when L is (N-methylene)piperidin-4-yl, then Z is N-sulfonamido, N(aryl)sulfonamido, 2,3-dihydro-2-oxo-1H-benzimidazol-1-yl, benzamido, phenylureido, phenylacetamido or (phenoxy)carbonylamino;
• when L is (N-methylene)-4-acetyl-piperidin-4-yl, then Z is phenyl or naphthyl and Y is carbonyl;
• and when L is (N-methylene)piperidin-4,4-diyl, then Z is 1-aryl-2,3-dihydro-4-oxo-imidazol-5,5-diyl and Y is carbonyl;
• and enantiomers, diastereomers and pharamaceutically acceptable salts thereof.