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US 7,071,191 B2Granted
Non-imidazole aryloxypiperidines
AssigneeOrtho-McNeil Pharmaceutical, Inc.
InventorsRichard Apodaca, Nicholas I. Carruthers, Curt A. Dvorak, Chandravadan R. Shah, Wei Xiao
Life of this patent
Estimating the term…
Abstract
Substituted non-imidazole aryloxypiperidine compounds, compositions containing them, and methods of making and using them to treat or prevent histamine-mediated conditions.
Claims17
A compound of formula (I):
- wherein X is O;
- n is an integer from 0 to 3;
- R5 is C1-10alkyl, C3-8alkenyl, C3-8cycloalkyl, (C3-8cycloalkyl) C1-6alkyl, (phenyl)C1-6alkyl, (phenyl)C3-8alkenyl, or (C1-8alkylcarbonyl)C1-8alkyl;
- one of R1, R2, and R3 is W or G, wherein one of the remaining two is selected from H and halogen, and the third being hydrogen;
- W is piperazinyl or morpholinyl;
- G is piperazinylmethyl or morpholinylmethyl;
- wherein each of the above alkyl, alkylene, alkenyl, alkenylene, alkynyl, alkynylene, heterocyclyl, cycloalkyl, and aryl groups may each be independently and optionally substituted with between 1 and 3 substituents selected from halo, amino, nitro, hydroxyl, and C1-3alkyl;
- or a pharmaceutically acceptable salt, ester, or amide thereof.
5 more elements
Dependencies are inferred from the claim text.