Methods and therapeutic combinations for the treatment of diabetes using sterol absorption inhibitors
AssigneeSchering Corporation
InventorsHarry R. Davis, Teddy Kosoglou, Gilles J. Picard, Rudyard J. Ress, John T. Strony, Enrico P. Veltri
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Abstract
The present invention provides methods of treating diabetes and associated conditions by administering a composition including at least one sterol or 5α-stanol absorption inhibitor or compositions or therapeutic combinations including: (a) at least one antidiabetic medication; and (b) at least one sterol or 5α-stanol absorption inhibitor.
Claims34
A composition comprising:
- (a) at least one antidiabetic medication selected from the group consisting of sulfonylurea, meglitinide, biguanide, thiazolidinedione, alpha-glucosidase inhibitor;
- peptide for increasing insulin production, and combinations thereof for reducing blood glucose levels in a subject;
- and
- (b) at least one sterol absorption inhibitor or at least one 5α-stanol absorption inhibitor, or a pharmaceutically acceptable salt or solvate thereof.
A therapeutic combination comprising:
- (a) a first amount of at least one antidiabetic medication selected from the group consisting of sulfonylurea, meglitinide, biguanide, thiazolidinedione, alpha-glucosidase inhibitor;
- peptide for increasing insulin production, and combinations thereof for reducing blood glucose levels in a subject;
- and
- (b) a second amount of at least one sterol or 5α-stanol absorption inhibitor;
- wherein the first amount and the second amount together comprise a therapeutically effective amount for the treatment of diabetes or lowering a concentration of a sterol or 5α-stanol in plasma of a subject.
A composition comprising:
- (a) at least one antidiabetic medication selected from the group consisting of sulfonylurea, meglitinide, biguanide, thiazolidinedione, alpha-glucosidase inhibitor;
- peptide for increasing insulin production, and combinations thereof;
- and (b) at least one substituted azetidinone compound or a pharmaceutically acceptable salt thereof or a solvate thereof.
A therapeutic combination comprising:
- (a) a first amount of at least one antidiabetic medication selected from the group consisting of sulfonylurea, meglitinide, biguanide, thiazolidinedione, alpha-glucosidase inhibitor;
- peptide for increasing insulin production, and combinations thereof for reducing blood glucose levels in a subject;
- and
- (b) a second amount of at least one substituted azetidinone compound or a pharmaceutically acceptable salt thereof or a solvate thereof, wherein the first amount and the second amount together comprise a therapeutically effective amount for the treatment of diabetes or lowering a concentration of a sterol or 5α-stanol in plasma of a subject.
A method of treating diabetes in a subject, comprising the step of administering to a subject in need of such treatment an effective amount of a composition comprising at least one sterol or 5α-stanol absorption inhibitor.
A method of treating diabetes in a subject, comprising the step of administering to a subject in need of such treatment an effective amount of a composition comprising at least one sterol or 5α-stanol absorption inhibitor represented by Formula (II) below:
Dependencies are inferred from the claim text.