Method and composition for inhibiting cholesterol esterase
AssigneeCV Therapeutics, Inc.
InventorsLouis G. Lange, III, Curtis A. Spilburg, Dayton T. Reardan
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Abstract
This invention encompasses methods for manufacturing purified, high molecular weight sulfated polysaccharide compositions that inhibit pancreatic cholesterol esterase and lower cholesterol in the blood stream.
Claims6
A method for lowering serum cholesterol in humans comprising administering to a human the combination of an essentially non-absorbable very high molecular weight sulfated polysaccharide having less than about 0.98 wt. percent of sulfated polysaccharides having a molecular weight less than 75,000 Daltons and containing less than 0.5 weight percent of inorganic sulfate and a second compound that reduces serum cholesterol levels wherein the high molecular weight sulfated polysaccharide is prepared by sulfating a very high molecular weight polysaccharide with a sulfur containing compound at a temperate less than about 20° C.
A method for lowering serum cholesterol in humans comprising administering to a human the combination of an essentially non-absorbable very high molecular weight sulfated cellulose having less than about 0.98 wt. percent of sulfated cellulose having a molecular weight less than 75,000 Daltons and containing less than 0.5 weight percent of inorganic sulfate and lovastatin wherein the high molecular weight sulfated polysaccharide is prepared by sulfating a very high molecular weight polysaccharide with a sulfur containing compound at a temperature less than about 20° C.
Dependencies are inferred from the claim text.