Secretion signal vectors

A delivery vector comprising:

• a) an adenovirus associated (AAV) vector genome comprising 5′ and 3′ AAV inverted terminal repeat (ITR) sequences;
• b) a first nucleotide sequence encoding a polypeptide of interest;
• and
• c) a second nucleotide sequence encoding a fibronectin secretory signal sequence that is operatively associated with the first nucleotide sequence of (b), wherein the second nucleotide sequence is selected from the group consisting of:
• (i) the nucleotide sequence of SEQ ID NO:1, SEQ ID NO:14 or SEQ ID NO:15;
• (ii) a nucleotide sequence encoding the amino acid sequence of SEQ ID NO:2 or an active fragment thereof having secretory signal activity, SEQ ID NO:5 or an active fragment thereof having secretory signal activity, or SEQ ID NO:6 or an active fragment thereof having secretory signal activity;
• and
• a nucleotide sequence that differs from the nucleotide sequence of (ii) above due to the degeneracy of the genetic code,
• and wherein the second nucleotide sequence does not contain nucleic acids that encode fibronectin amino acid sequence beyond the carboxy terminal side of the cleavage site of the signal sequence.