Anti-cancer and wound healing compounds
AssigneeKimberly-Clark Worldwide, Inc.
InventorsStephen Quirk, Ilona F. Weart
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Abstract
The invention provides inhibitors of matrix metalloproteinases that are useful as anti-tumor agents and for treating wounds. The inhibitors are peptides having sequences related to cleavage regions of the proenzyme forms of matrix metalloproteinases. The peptide inhibitors of the invention can be formulated into therapeutic compositions, lotions, creams, skin covering and wound dressings that inhibit expression of vascular endothelial growth factor and encourage healing.
Claims11
A method for decreasing expression of vascular endothelial growth factor that comprises contacting a cell comprising a gene for vascular endothelial growth factor with an effective amount of a peptide that comprises SEQ ID NO:11, SEQ ID NO:12, or SEQ ID NO:13.
Dependencies are inferred from the claim text.