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US 7,071,163 B2Granted
Compounds for targeting hepatocytes in vivo
AssigneeMirus Bio Corporation
InventorsAlexander V. Sokoloff, So Wong, Jon A. Wolff, Sean D. Monahan, James Ludtke, Lori Higgs, Darren Wakefield, Magdolna G. Sebestyén
Life of this patent
Estimating the term…
Abstract
We describe compounds that bind to and are internalized by hepatocytes. Association of these compounds to other molecules or complexes can be used to target the molecules or complexes to hepatocytes in vivo or in vitro.
Claims20
A composition for targeting hepatocytes comprising:
- a T7 ligand covalently attached to a compound, wherein,
- a) said T7 ligand is selected from the group consisting of:
- T7 p17 protein, modified T7 p17 protein, T7 p17 rod domain, T7 p17 coiled coil domain, SEQ ID NO:
- 1, SEQ ID NO:
- 14, SEQ ID NO:
- 15, SEQ ID NO:
- 16, SEQ ID NO:
- 17, SEQ ID NO:
- 18, SEQ ID NO:
- 19, SEQ ID NO:
- 20, SEQ ID NO:
- 21, SEQ ID NO:
- 22, SEQ ID NO:
- 23, SEQ ID NO:
- 24, and
- b) said compound is selected from the group consisting of:
- drug, component of a drug or polynucleotide complex and polynucleotide.
14 more elements
A pharmaceutical preparation comprising:
- a compound selected from the group consisting of:
- drug, component of a drug or polynucleotide complex, and polynucleotide covalently attached to a T7 ligand selected from the group consisting of:
- T7 p17 protein, modified T7 p17 protein, T7 p17 rod domain, T7 p17 coiled coil domain, SEQ ID NO:
- 1, SEQ ID NO:
- 14, SEQ ID NO:
- 15, SEQ ID NO:
- 16, SEQ ID NO:
- 17, SEQ ID NO:
- 18, SEQ ID NO:
- 19, SEQ ID NO:
- 20, SEQ ID NO:
- 21, SEQ ID NO:
- 22, SEQ ID NO:
- 23, SEQ ID NO:
- 24.
12 more elements
A composition for targeting hepatocytes in vivo comprising:
- a T7 ligand covalently attached to a compound, wherein
- a) said T7 ligand is selected from the group consisting of:
- T7 p17 protein, modified T7 p17 protein, T7 p17 rod domain, T7 p17 coiled coil domain, SEQ ID NO:
- 1, SEQ ID NO:
- 14, SEQ ID NO:
- 15, SEQ ID NO:
- 16, SEQ ID NO:
- 17, SEQ ID NO:
- 18, SEQ ID NO:
- 19, SEQ ID NO:
- 20, SEQ ID NO:
- 21, SEQ ID NO:
- 22, SEQ ID NO:
- 23, SEQ ID NO:
- 24, and
- b) said compound is selected from the group consisting of:
- drug, component of a drug or polynucleotide complex and polynucleotide.
14 more elements
Dependencies are inferred from the claim text.