Variants of corticotropin releasing hormone receptor Type 1 and uses thereof
AssigneeThe University of Tennessee Research Corporation
InventorsAlexander Pisarchik, Andrzej Slominski
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Abstract
The present invention identifies four new isoforms of human corticotropin releasing hormone receptor type 1 (CRH-R1e, 1f, 1g and 1h) and three new isoforms of mouse corticotropin releasing hormone receptor type 1 (mCRH-R1c, 1e and 1f). The data indicate that polymorphism of CRH-R1 expression is related to anatomic location, skin physiological or pathologic status, specific cell type, external stress (UV), and that cAMP dependent pathways and TPA may regulate CRH-R1.
Claims2
An isolated corticotropin releasing hormone receptor type 1 protein comprising the amino acid sequence SEQ ID No:
- 5.
Dependencies are inferred from the claim text.