Insulin-like growth factor-binding protein
AssigneeKyowa Hakko Kogyo Co., Ltd.
InventorsKazuya Yamano, Susumu Sekine, Mitsuo Satoh, Toshio Ota, Akiko Furuya, Kenji Shibata, Yuki Kobayashi, Miho Takebayashi, Yusuke Nakamura, Sumio Sugano
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Abstract
Using the proteins of the present invention, DNAs encoding the proteins, and antibodies recognizing the proteins, detection methods for diseases relating to the novel insulin-like growth factor binding proteins of the present invention, as well as diagnostic agents, preventive agents, and therapeutic agents for diseases relating to the proteins of the present invention can be provided.
Claims6
An isolated protein, which comprises the amino acid sequence represented by SEQ ID NO:
- 2.
An isolated protein comprising an amino acid sequence that includes the 75th to the 82nd amino acid residues of the amino acid sequence represented by SEQ ID NO:
- 2, wherein the protein binds to insulin-like growth factor.
The medicament according to 4, wherein the medicament is a diagnostic agent, a preventive agent, or a therapeutic agent for diseases accompanying abnormal cell growth, diseases accompanying angiopathy, diseases accompanying abnormal bone metabolism, diseases accompanying disorders of insulin-like growth factors or growth hormone action, diseases accompanying abnormal differentiation or growth of smooth muscle cells, diseases accompanying abnormal differentiation or growth of skeletal muscle cells, diseases accompanying abnormal gastric acid secretion, or inflammatory diseases accompanying abnormal lymphocyte invasion.
Dependencies are inferred from the claim text.